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Phospho-PTEN(T383) Antibody

Phospho-PTEN(T383) Antibody

Item no.	ABC-AP3788f-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Oncology Metabolism Diabetes Antibodies Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Adenocarcinoma Primary Antibodies Dot Blot
Type	Antibody Polyclonal
Applications	Dot blot
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Phosphatidylinositol 3,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog, PTEN, MMAC1, TEP1
Available
Primary Accession	P60484
Other Accession	Q9PUT6; O08586; NP_000305.3
Antigen Type	Synthetic Peptide
Bio Background	This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
Bio References	Miletic, A.V., et al. J. Exp. Med. 207(11):2407-2420(2010) Kini, V., et al. J. Biol. Chem. 285(43):33082-33091(2010) Shimada, M., et al. Hum. Genet. 128(4):433-441(2010) Molina, J.R., et al. Cancer Res. 70(17):6697-6703(2010) Iliopoulos, D., et al. Mol. Cell 39(4):493-506(2010)
Gene ID	5728
Gene Name	PTEN
Reactivity	H
Predicted	M, X
Calculated MW	47166
Antigen Source	HUMAN
Target/Specificity	This PTEN Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T383 of human PTEN.
NCBI Accession	NP_000305.3

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 80 ul

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