Item no. |
ABC-AP3782g-ev-80ul |
Manufacturer |
Abcepta
|
Amount |
80 ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
Dot blot |
Specific against |
other |
Host |
Rabbit |
Isotype |
Ig |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B-kinase beta, IKK-B, IKK-beta, IkBKB, I-kappa-B kinase 2, IKK2, Nuclear factor NF-kappa-B inhibitor kinase beta, NFKBIKB, IKBKB, IKKB |
Available |
|
Primary Accession |
O14920 |
Other Accession |
Q9QY78; O88351; Q95KV0; NP_001177649.1 |
Antigen Type |
Synthetic Peptide |
Bio Background |
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). |
Bio References |
Yatherajam, G., et al. J. Immunol. 185(5):2665-2669(2010) Kenneth, N.S., et al. EMBO J. 29(17):2966-2978(2010) Zhao, M., et al. J. Biol. Chem. 285(32):24372-24380(2010) Niida, M., et al. Mol. Immunol. 47(14):2378-2387(2010) Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010) |
Gene ID |
3551 |
Gene Name |
IKBKB |
Reactivity |
H |
Predicted |
B, M, Rat |
Calculated MW |
86564 |
Antigen Source |
HUMAN |
Target/Specificity |
This IKKB Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S672 of human IKKB. |
NCBI Accession |
NP_001177649.1; NP_001229707.1; NP_001547.1 |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.