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Phospho-ABL(Y204) Antibody

Phospho-ABL(Y204) Antibody

Item no.	ABC-AP3481a-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Oncology Neuroscience Protein Aggregation, Clearance & Misfolding Antibodies Carcinoma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Immunofluorescence Primary Antibodies Heart & Blood Cancer Dot Blot
Type	Antibody Polyclonal
Applications	Immunofluorescence, Dot blot
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150, ABL1, ABL, JTK7
Available
Primary Accession	P00519
Other Accession	P00520; F8W5Q8
Antigen Type	Synthetic Peptide
Bio Background	ABL1 is a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9; 22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.
Bio References	Barnes, K., et al., Oncogene 24(20):3257-3267 (2005). Kim, Y.R., et al., Genes Chromosomes Cancer 43(1):37-44 (2005). Aichberger, K.J., et al., Blood 105(8):3303-3311 (2005). Wei, G., et al., J. Biol. Chem. 280(13):12271-12278 (2005). Robinson, H.M., et al., Leukemia 19(4):564-571 (2005).
Gene ID	25
Gene Name	ABL1
Reactivity	H
Predicted	Zf, M
Calculated MW	122873
Antigen Source	HUMAN
Target/Specificity	This ABL Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y185 of human ABL.
NCBI Accession	NP_005148.2; NP_009297.2

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Amount: 80 ul

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