Alias |
Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150, ABL1, ABL, JTK7 |
Bio Background |
ABL1 is a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9; 22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. |
Bio References |
Barnes, K., et al., Oncogene 24(20):3257-3267 (2005). Kim, Y.R., et al., Genes Chromosomes Cancer 43(1):37-44 (2005). Aichberger, K.J., et al., Blood 105(8):3303-3311 (2005). Wei, G., et al., J. Biol. Chem. 280(13):12271-12278 (2005). Robinson, H.M., et al., Leukemia 19(4):564-571 (2005). |