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Phospho-RAF1(S259) Antibody

Phospho-RAF1(S259) Antibody

Item no.	ABC-AP3443a
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	Dot
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 5.1	32160702
ECLASS 6.1	32160702
ECLASS 8.0	32160702
ECLASS 9.0	32160702
ECLASS 10.0.1	32160702
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	RAF1, Raf-1, RAF proto-oncogene serine/threonine-protein kinase, Proto-oncogene c-RAF, RAF, cRaf
Available
Primary Accession	P04049
Antigen Type	Synthetic Peptide
Application	DB
Bio Background	Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration.
Bio References	Dasgupta, P., et al., Mol. Cell. Biol. 24(21):9527-9541 (2004). Ku, N.O., et al., J. Cell Biol. 166(4):479-485 (2004). Gohlke, H., et al., Proteins 56(2):322-337 (2004). Akula, S.M., et al., Oncogene 23(30):5227-5241 (2004). Goetz, C.A., et al., J. Immunol. 172(8):4770-4778 (2004).
Clonality	Polyclonal
Clone/Animal Names	RB11131
Gene ID	5894
Gene Name	RAF1
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Dot blot analysis of anti-RAF1-pS259 Phospho-specific Pab (RB11131) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
Type image 1	DB
Dilution image 1	1:500
Isotype	Rabbit Ig
Calculated MW	73052
Antigen Source	HUMAN
Target/Specificity	This Phospho-RAF1-S259 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S259 of human RAF1.
NCBI Accession	NP_002871.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 9/6/2024

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