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Phospho-SEPARIN(S1126) Antibody

Phospho-SEPARIN(S1126) Antibody

Item no.	ABC-AP3247a-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Oncology Antibodies Hematology Leukemia Lymphoma Immunohistochemistry Primary Antibodies Dot Blot
Type	Antibody Polyclonal
Applications	Dot blot, Immunohistochemistry
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Separin, Caspase-like protein ESPL1, Extra spindle poles-like 1 protein, Separase, ESPL1, ESP1, KIAA0165
Available
Primary Accession	Q14674
Antigen Type	Synthetic Peptide
Bio Background	The metaphase-to-anaphase transition is the final discrete event in duplication and separation of the genetic material of the cell. Its timing is regulated by the activation of the anaphase-promoting complex (APC). In both budding and fission yeast, the degradation of the Pds1 or Cut2 protein, respectively, is required for the onset of sister chromatid separation. Both proteins are APC substrates. Pds1 and Cut2 proteins associate with the yeast separin proteins Esp1 and Cut1, respectively, and prevent the separins from promoting chromatid separation. Pds1 and Cut2 are also called anaphase inhibitors or securins
Bio References	Chestukhin, A., et al., Proc. Natl. Acad. Sci. U.S.A. 100(8):4574-4579 (2003). Waizenegger, I., et al., Curr. Biol. 12(16):1368-1378 (2002). Chen, F., et al., J. Biol. Chem. 277(19):16775-16781 (2002). Hauf, S., et al., Science 293(5533):1320-1323 (2001). Zou, H., et al., Science 285(5426):418-422 (1999).
Gene ID	9700
Gene Name	ESPL1
Reactivity	H
Calculated MW	233175
Antigen Source	HUMAN
Target/Specificity	This SEPARIN Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1126 of human SEPARIN.
NCBI Accession	NP_036423.4

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Amount: 80 ul

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