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Phospho-DAXX(S213) Antibody

Phospho-DAXX(S213) Antibody

Item no.	ABC-AP3082a
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	Daxx, DAXX, BING2, DAP6, Death domain-associated protein 6, ETS1-associated protein 1, Fas death domain-associated protein, EAP1, hDaxx
Available
Primary Accession	Q9UER7
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	DAXX is proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. DAXX seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. This protein down-regulates basal and activated transcription, and it also seems to act as a transcriptional co-repressor and inhibits PAX3 and ETS1 through direct protein-protein interaction. DAXX modulates PAX5 activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively.
Bio References	Cantrell, S.R., et al., J. Virol. 79(12):7792-7802 (2005). Greger, J.G., et al., J. Virol. 79(8):4610-4618 (2005). Chang, C.C., et al., J. Biol. Chem. 280(11):10164-10173 (2005). Beausoleil, S.A., et al., Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135 (2004). Gostissa, M., et al., J. Biol. Chem. 279(46):48013-48023 (2004).
Clonality	Polyclonal
Clone/Animal Names	RB6929
Gene ID	1616
Gene Name	DAXX
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	The anti-Phospho-DAXX-S213 Pab (Cat. #AP73082a) is used in Western blot to detect Phospho-DAXX-S213 in mouse thymus tissue lysate
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Type image 2	IHC-P
Dilution image 2	1:50~100
Other Accession	Q8VIB2; O35613
Predicted	M, Rat
Isotype	Rabbit Ig
Calculated MW	81373
Antigen Source	HUMAN
Target/Specificity	This DAXX Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S213 of human DAXX.
NCBI Accession	NP_001135441.1; NP_001241646.1; NP_001341.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 10/4/2024

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