Bio Background |
The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein-Barr virus in order to enhance programed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK. |
Bio References |
Nikrad, M., et al., Mol. Cancer Ther. 4(3):443-449 (2005).Dong, F., et al., Infect. Immun. 73(3):1861-1864 (2005).Hur, J., et al., Proc. Natl. Acad. Sci. U.S.A. 101(8):2351-2356 (2004).Gillissen, B., et al., EMBO J. 22(14):3580-3590 (2003).Arena, V., et al., Genes Chromosomes Cancer 38(1):91-96 (2003). |
Legend image 2 |
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. |