Item no. |
ABC-AP22211c-ev-50ul |
Manufacturer |
Abcepta
|
Amount |
50 ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
Immunofluorescence, Western Blot, Flow cytometry, Immunohistochemistry |
Specific against |
other |
Host |
Rabbit |
Isotype |
Ig |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
3-hydroxyacyl-CoA dehydrogenase type-2, 1.1.1.35, 17-beta-hydroxysteroid dehydrogenase 10, 17-beta-HSD 10, 1.1.1.51, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase, 1.1.1.178, 3-hydroxyacyl-CoA dehydrogenase type II, Endoplasmic reticulum-associated amyloid |
Available |
|
Primary Accession |
Q99714 |
Other Accession |
O02691; O08756; O70351 |
Antigen Type |
Synthesized Peptide |
Bio Background |
Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). |
Bio References |
Yan S.D., et al.Nature 389:689-695(1997). Zhuchenko O.P., et al.Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases. Miller A.P., et al.Proc. Natl. Acad. Sci. U.S.A. 95:8709-8714(1998). He X.Y., et al.J. Biol. Chem. 273:10741-10746(1998). Ebert L., et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. |
Gene ID |
3028 |
Gene Name |
HSD17B10 |
Reactivity |
H, M, Rat |
Predicted |
B |
Calculated MW |
26923 |
Antigen Source |
HUMAN |
Target/Specificity |
This HSD17B10 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 140-172 amino acids from the Central region of human HSD17B10. |
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