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MLL3 Antibody (C-term)

MLL3 Antibody (C-term)

Item no.	ABC-AP22080b-ev
Manufacturer	Abcepta
Amount	50 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	MLL3, HALR, KIAA1506, KMT2C, Homologous to ALR protein, Lysine N-methyltransferase 2C, Myeloid/lymphoid or mixed-lineage leukemia protein 3, Histone-lysine N-methyltransferase 2C, 2.1.1.43
Available
Primary Accession	Q8NEZ4
Antigen Type	Synthesized Peptide
Application	IHC-P
Bio Background	Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.
Bio References	Ruault M., et al.Gene 284:73-81(2002). Tan Y.C., et al.Cancer Detect. Prev. 25:454-469(2001). Hillier L.W., et al.Nature 424:157-164(2003). Nagase T., et al.DNA Res. 7:143-150(2000). Nakajima D., et al.DNA Res. 9:99-106(2002).
Clonality	polyclonal
Clone/Animal Names	RB52486
Gene ID	58508
Gene Name	KMT2C
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	AP22080b staining MLL3 in human testis tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.
Type image 1	IHC-P
Dilution image 1	1:25
Isotype	Rabbit Ig
Calculated MW	541370
Antigen Source	HUMAN
Target/Specificity	This MLL3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 3784-3818 amino acids from the C-terminal region of human MLL3.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ul

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Delivery expected until 9/6/2024

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