Item no. |
ABC-AP21660a-ev |
Manufacturer |
Abcepta
|
Amount |
50 ul |
Category |
|
Type |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applications |
WB |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
IMP4, SPPL2B, PSL1, Signal peptide peptidase-like 2B, Intramembrane protease 4, KIAA1532, PSH4, IMP-4, 3423-, SPP-like 2B, SPPL2b, Presenilin homologous protein 4, Presenilin-like protein 1 |
Available |
|
Primary Accession |
Q8TCT7 |
Application |
WB |
Bio Background |
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF- alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity. |
Bio References |
Irmler M., et al.Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.Martoglio B., et al.Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.Grigorenko A.P., et al.Biochemistry (Mosc.) 67:826-834(2002).Nagase T., et al.DNA Res. 7:143-150(2000).Grimwood J., et al.Nature 428:529-535(2004). |
Clonality |
polyclonal |
Clone/Animal Names |
RB53138 |
Gene ID |
56928 |
Gene Name |
SPPL2B {ECO:0000303|PubMed:15385547, ECO:0000312|HGNC:HGNC:30627} |
Subtitle |
Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
All lanes : Anti-SPPL2B Antibody (N-Term) at 1:2000 dilutionLane 1: Hela whole cell lysateLane 2: HT-29 whole cell lysateLane 3: Jurkat whole cell lysateLane 4: KG-1 whole cell lysateLane 5: Ramos whole cell lysateLysates/proteins at 20 µg per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 65 kDaBlocking/Dilution buffer: 5% NFDM/TBST. |
Type image 1 |
WB |
Dilution image 1 |
1:2000 |
Isotype |
Rabbit Ig |
Calculated MW |
64644 |
Antigen Source |
HUMAN |
Target/Specificity |
This SPPL2B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 126-160 amino acids from human SPPL2B. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.