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NGEF Antibody (C-term)

NGEF Antibody (C-term)

Manufacturer	Abcepta
Category	Antibodies Western Blot Primary Antibodies
Type	Antibody Polyclonal
Specific against	other
Isotype	Ig
Applications	Western Blot
Amount	50 ul
Host	Rabbit
Item no.	ABC-AP21607b-ev-50ul
Targets	SOS1
eClass 6.1	32160702
eClass 9.0	32160702
Available
Alias	Ephexin-1, Eph-interacting exchange protein, Neuronal guanine nucleotide exchange factor, NGEF
Primary Accession	Q8N5V2
Bio Background	Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
Bio References	Ota T., et al.Nat. Genet. 36:40-45(2004). Hillier L.W., et al.Nature 434:724-731(2005). Rodrigues N.R., et al.Genomics 65:53-61(2000).
Gene ID	25791
Gene Name	NGEF
Reactivity	H
Calculated MW	82496
Antigen Source	HUMAN
Target/Specificity	This NGEF antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 669-704 amino acids from the C-terminal region of human NGEF.

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Amount: 50 ul

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