Item no. |
ABC-AP21563c |
Manufacturer |
Abcepta
|
Amount |
200 ul |
Category |
|
Type |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applications |
WB |
Specific against |
other |
Host |
Rabbit |
Isotype |
Ig |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
COPS5, CSN5, JAB1, SGN5, COP9 signalosome complex subunit 5, Signalosome subunit 5, 34--, Jun activation domain-binding protein 1 |
Available |
|
Primary Accession |
Q92905 |
Application |
WB |
Bio Background |
Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2. |
Bio References |
Claret F.-X., et al.Nature 383:453-457(1996).Asano K., et al.J. Biol. Chem. 272:27042-27052(1997).Halleck A., et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.Bechtel S., et al.BMC Genomics 8:399-399(2007).Bienvenut W.V., et al.Submitted (OCT-2005) to UniProtKB. |
Clonality |
polyclonal |
Clone/Animal Names |
RB53049 |
Gene ID |
10987 |
Gene Name |
COPS5 |
Subtitle |
Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H, M, Rat |
Legend image 1 |
All lanes : Anti-COPS5 Antibody (Center) at 1:500-1:1000 dilutionLane 1: NIH/3T3 whole cell lysatesLane 2: U-87 MG whole cell lysatesLane 3: PC-12 whole cell lysatesLysates/proteins at 20 µg per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 38 kDaBlocking/Dilution buffer: 5% NFDM/TBST. |
Type image 1 |
WB |
Dilution image 1 |
1:500-1:1000 |
Isotype |
Rabbit Ig |
Calculated MW |
37579 |
Antigen Source |
HUMAN |
Target/Specificity |
This COPS5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 187-222 amino acids from the Central region of human COPS5. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.