Item no. |
ABC-AP2146b |
Manufacturer |
Abcepta
|
Amount |
400 ul |
Category |
|
Type |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applications |
WB, IHC-P |
Specific against |
other |
Host |
Rabbit |
Isotype |
Ig |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
USP20, KIAA1003, LSFR3A, VDU2, Ubiquitin carboxyl-terminal hydrolase 20, Deubiquitinating enzyme 20, Ubiquitin thioesterase 20, Ubiquitin-specific-processing protease 20, VHL-interacting deubiquitinating enzyme 2, hVDU2 |
Available |
|
Primary Accession |
Q9Y2K6 |
Antigen Type |
Synthetic Peptide |
Application |
IHC-P, WB |
Bio Background |
Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs), 1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions. |
Bio References |
Nagase, T., et al., DNA Res. 6(1):63-70 (1999).Gilley, J., et al., Hum. Mol. Genet. 8(7):1313-1320 (1999). |
Clonality |
Polyclonal |
Clone/Animal Names |
RB4351 |
Gene ID |
10868 |
Gene Name |
USP20 |
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
M |
Legend image 1 |
USP20 Antibody (E828) (Cat. #AP2146b) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the USP20 antibody detected the USP20 protein (arrow). |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Legend image 2 |
USP20 Antibody (C-term) (Cat. #AP2146b)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of USP20 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. |
Type image 2 |
IHC-P |
Dilution image 2 |
1:10~50 |
Other Accession |
A7Z056; NP_006667 |
Predicted |
B |
Isotype |
Rabbit Ig |
Calculated MW |
102003 |
Antigen Region |
814-844 |
Antigen Source |
HUMAN |
Target/Specificity |
This USP20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 814-844 amino acids from the C-terminal region of human USP20. |
NCBI Accession |
NP_001008563.2; NP_001103773.2; NP_006667.3 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.