Item no. |
ABC-AP21376b |
Manufacturer |
Abcepta
|
Amount |
400 ul |
Category |
|
Type |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applications |
WB |
Specific against |
other |
Host |
Rabbit |
Isotype |
Ig |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
Rps6ka5, RSK-like protein kinase, 90 kDa ribosomal protein S6 kinase 5, Nuclear mitogen- and stress-activated protein kinase 1, Ribosomal protein S6 kinase alpha-5, S6K-alpha-5, RLSK, Msk1 |
Available |
|
Primary Accession |
Q8C050 |
Application |
WB |
Bio Background |
Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential. Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto- oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro- inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti- inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury. |
Bio References |
Zhou G., et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.Carninci P., et al.Science 309:1559-1563(2005).Zhong S., et al.J. Biol. Chem. 276:33213-33219(2001).Zhang Y., et al.J. Biol. Chem. 276:42534-42542(2001).Wiggin G.R., et al.Mol. Cell. Biol. 22:2871-2881(2002). |
Clonality |
polyclonal |
Clone/Animal Names |
RB51314 |
Gene ID |
73086 |
Gene Name |
Rps6ka5 |
Subtitle |
Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
M |
Legend image 1 |
Anti-Rps6ka5 Antibody (C-term)at 1:4000 dilution + mouse heart lysatesLysates/proteins at 20 µg per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilutionPredicted band size : 97 kDaBlocking/Dilution buffer: 5% NFDM/TBST. |
Type image 1 |
WB |
Dilution image 1 |
1:4000 |
Isotype |
Rabbit Ig |
Calculated MW |
96583 |
Antigen Source |
HUMAN |
Target/Specificity |
This Mouse Rps6ka5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 780-815 amino acids from the C-terminal region of Mouse Rps6ka5. |
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