Item no. |
ABC-AP2134a-ev-80ul |
Manufacturer |
Abcepta
|
Amount |
80 ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
Western Blot, Immunohistochemistry |
Specific against |
other |
Host |
Rabbit |
Isotype |
Ig |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Ubiquitin carboxyl-terminal hydrolase 5, Deubiquitinating enzyme 5, Isopeptidase T, Ubiquitin thioesterase 5, Ubiquitin-specific-processing protease 5, USP5, ISOT |
Available |
|
Primary Accession |
P45974 |
Antigen Type |
Synthetic Peptide |
Bio Background |
Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs), 1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions. |
Bio References |
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002). Ansari-Lari, M.A., et al., Genome Res. 6(4):314-326 (1996). Falquet, L., et al., FEBS Lett. 376(3):233-237 (1995). Falquet, L., et al., FEBS Lett. 359(1):73-77 (1995). |
Gene ID |
8078 |
Gene Name |
USP5 |
Reactivity |
H |
Calculated MW |
95786 |
Antigen Region |
59-90 |
Antigen Source |
HUMAN |
Target/Specificity |
This USP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-90 amino acids from the N-terminal region of human USP5. |
NCBI Accession |
NP_001092006.1; NP_003472.2 |
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