Item no. |
ABC-AP21135a-ev |
Manufacturer |
Abcepta
|
Amount |
80 ul |
Category |
|
Type |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applications |
WB |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
CSK, Tyrosine-protein kinase CSK, C-Src kinase, Protein-tyrosine kinase CYL |
Available |
|
Primary Accession |
P41240 |
Application |
WB |
Bio Background |
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. |
Bio References |
Partanen J., et al.Oncogene 6:2013-2018(1991).Braeuninger A., et al.Proc. Natl. Acad. Sci. U.S.A. 88:10411-10415(1991).Brauninger A., et al.Gene 110:205-211(1992).Braeuninger A., et al.Oncogene 8:1365-1369(1993).Halleck A., et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. |
Clonality |
polyclonal |
Clone/Animal Names |
RB50499 |
Gene ID |
1445 |
Gene Name |
CSK |
Subtitle |
Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
Western blot analysis of lysate from Ramos cell line, using CSK Antibody (Center)(Cat. #AP21135a). AP21135a was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug. |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Other Accession |
P32577; P41241; Q0VBZ0 |
Isotype |
Rabbit Ig |
Calculated MW |
50704 |
Antigen Source |
HUMAN |
Target/Specificity |
This CSK antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 164-197 amino acids from the Central region of human CSK. |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.