Item no. |
ABC-AP21095a-ev |
Manufacturer |
Abcepta
|
Amount |
80 ul |
Category |
|
Type |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applications |
WB |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
GSK3A, Glycogen synthase kinase-3 alpha, Serine/threonine-protein kinase GSK3A, GSK-3 alpha |
Available |
|
Primary Accession |
P49840 |
Application |
WB |
Bio Background |
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. |
Bio References |
He X., et al.Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases.Hoshino T., et al.Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.Grimwood J., et al.Nature 428:529-535(2004).Nikoulina S.E., et al.Diabetes 49:263-271(2000).Phiel C.J., et al.Nature 423:435-439(2003). |
Clonality |
Polyclonal |
Clone/Animal Names |
RB30809 |
Gene ID |
2931 |
Gene Name |
GSK3A |
Subtitle |
Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
M, Rat |
Legend image 1 |
Western blot analysis of lysates from mouse NIH/3T3 cell line, rat brain tissue lysate(from left to right), using GSK3A Antibody (Center)(Cat. #AP21095a). AP21095a was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane. |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Other Accession |
Q91757; P18266; Q9WV60; P49841; P18265; Q2NL51 |
Predicted |
H, X |
Isotype |
Rabbit Ig |
Calculated MW |
50981 |
Antigen Source |
HUMAN |
Target/Specificity |
This GSK3A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 348-382 amino acids from the Central region of human GSK3A. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.