KLF4 Antibody (C-term)

O43474

Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.

Polyclonal

9314

Purified Rabbit Polyclonal Antibody (Pab)

Western blot analysis of lysate from NCCIT cell line, using KLF4 Antibody (C-term)(Cat. #AP21041a). AP21041a was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.

1:1000

54671

This KLF4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 408-450 amino acids from the C-terminal region of human KLF4.