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LIN7B Antibody (N-term)

LIN7B Antibody (N-term)

Item no.	ABC-AP19782a-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Antibodies Western Blot Primary Antibodies
Type	Antibody Polyclonal
Applications	Western Blot
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Protein lin-7 homolog B, Lin-7B, hLin7B, Mammalian lin-seven protein 2, MALS-2, Vertebrate lin-7 homolog 2, Veli-2, hVeli2, LIN7B, MALS2, VELI2
Available
Primary Accession	Q9HAP6
Other Accession	Q9Z252; O88951; Q2KIB6; NP_071448.1
Antigen Type	Synthetic Peptide
Bio Background	Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity).
Bio References	Zucker, B., et al. J. Neuropathol. Exp. Neurol. 69(9):880-895(2010) Lanktree, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (6), 945-951 (2008) : Sudo, K., et al. Neurosci. Res. 56(4):347-355(2006) Li, Z., et al. J. Biol. Chem. 281(16):11066-11073(2006) Kawai, S., et al. J. Biol. Chem. 280(47):39200-39207(2005)
Gene ID	64130
Gene Name	LIN7B
Reactivity	H, M
Predicted	B, Rat
Calculated MW	22896
Antigen Region	35-62
Antigen Source	HUMAN
Target/Specificity	This LIN7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-62 amino acids from the N-terminal region of human LIN7B.
NCBI Accession	NP_071448.1

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Amount: 80 ul

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