Bio Background |
The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. |
Bio References |
Dvorin, J.D., et al., J. Virol. 76(23):12087-12096 (2002).Limon, A., et al., J. Virol. 76(21):10598-10607 (2002).Hariton-Gazal, E., et al., Biochim. Biophys. Acta 1594(2):234-242 (2002).Depienne, C., et al., J. Biol. Chem. 276(21):18102-18107 (2001).Bouyac-Bertoia, M., et al., Mol. Cell 7(5):1025-1035 (2001). |