Item no. |
ABC-AP19409c-ev |
Manufacturer |
Abcepta
|
Amount |
80 ul |
Category |
|
Type |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applications |
WB |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
Viral integration site protein INT-6 homolog, Eukaryotic translation initiation factor 3 subunit E {ECO:0000255|HAMAP-Rule:MF_03004}, eIF3e {ECO:0000255|HAMAP-Rule:MF_03004}, Eukaryotic translation initiation factor 3 subunit 6 {ECO:0000255|HAMAP-Rule:MF_03004}, eIF-3 p48 {ECO:0000255|HAMAP-Rule:MF_03004}, EIF3E {ECO:0000255|HAMAP-Rule:MF_03004} |
Available |
|
Primary Accession |
P60228 |
Antigen Type |
Synthetic Peptide |
Application |
WB |
Bio Background |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins. |
Bio References |
Grzmil, M., et al. Oncogene 29(28):4080-4089(2010)Zhou, M., et al. Proc. Natl. Acad. Sci. U.S.A. 105(47):18139-18144(2008)Masutani, M., et al. EMBO J. 26(14):3373-3383(2007)Morris, C., et al. EMBO Rep. 8(6):596-602(2007)Sirchia, R., et al. Biol. Chem. 388(5):457-465(2007) |
Clonality |
Polyclonal |
Clone/Animal Names |
RB40515 |
Gene ID |
3646 |
Gene Name |
EIF3E {ECO:0000255|HAMAP-Rule:MF_03004} |
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H, Zf |
Legend image 1 |
(DANRE) eif3eb Antibody (Center) (Cat.# AP19409c) western blot analysis in zebra fish brain tissue lysates (35ug/lane).This demonstrates the (DANRE) eif3eb antibody detected the (DANRE) eif3eb protein (arrow). |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Legend image 2 |
EIF3E Antibody (Center)(Cat. #AP19409c) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the EIF3E antibody detected the EIF3E protein (arrow). |
Type image 2 |
WB |
Dilution image 2 |
1:1000 |
Other Accession |
Q641X8; P60229; Q4R6G8; Q5ZLA5; Q3T102; Q3B8M3; Q1LUA8; Q05AY2; Q6DRI1; NP_001559.1 |
Predicted |
X, B, C, Pr, M, Rat |
Isotype |
Rabbit Ig |
Calculated MW |
52221 |
Antigen Region |
248-276 |
Antigen Source |
HUMAN |
Target/Specificity |
This EIF3E antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 248-276 amino acids from the Central region of human EIF3E. |
NCBI Accession |
NP_001559.1 |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.