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DEFA3 Antibody (C-term)

DEFA3 Antibody (C-term)

Manufacturer	Abcepta
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Specific against	other
Isotype	Ig
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB, IHC-P
Amount	400 ul
Host	Rabbit
Item no.	ABC-AP19266b
eClass 6.1	32160702
eClass 9.0	32160702
Available
Primary Accession	P59666
Antigen Type	Synthetic Peptide
Application	IHC-P-Leica, WB
Bio Background	Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation.
Bio References	Han, S., et al. Hum. Immunol. 71(7):727-730(2010) Chen, Q., et al. Anesthesiology 112(6):1428-1434(2010) Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010) Paslakis, G., et al. Nephron Exp. Nephrol. 115 (4), E96-E100 (2010) : Rodriguez-Garcia, M., et al. PLoS ONE 5 (2), E9436 (2010) :
Clonality	Polyclonal
Clone/Animal Names	RB30594
Gene ID	1668
Gene Name	DEFA3
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	DEFA3 Antibody (C-term)(Cat. #AP19266b) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the DEFA3 antibody detected the DEFA3 protein (arrow).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Immunohistochemical analysis of AP19266b on paraffin-embedded human spleen tissue was performed on the Leica® BOND RXm. Tissue was fixed with formaldehyde at room temperature. Heat induced epitope retrieval was performed by EDTA buffer (pH9. 0). Samples were incubated with primary antibody(1:500) for 15min at room temperature. Leica Bond Polymer Refine Detection was used as the secondary antibody.
Type image 2	IHC-P-Leica
Dilution image 2	1:500
Other Accession	NP_005208.1
Isotype	Rabbit Ig
Calculated MW	10245
Antigen Region	38-65
Antigen Source	HUMAN
Target/Specificity	This DEFA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-65 amino acids from the C-terminal region of human DEFA3.
NCBI Accession	NP_005208.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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ABC-AP19266b-datasheet.pdf

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Amount: 400 ul

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Delivery expected until 9/6/2024

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