Item no. |
ABC-AP19229b-ev |
Manufacturer |
Abcepta
|
Amount |
80 ul |
Category |
|
Type |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applications |
WB |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
Chromobox protein homolog 5, Heterochromatin protein 1 homolog alpha, Cbx5, Hp1a, HP1 alpha |
Available |
|
Primary Accession |
Q61686 |
Antigen Type |
Synthetic Peptide |
Application |
WB |
Bio Background |
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (By similarity). |
Bio References |
Sun, Y., et al. Biophys. J. 99(4):1274-1283(2010)Muller, K.P., et al. Biophys. J. 97(11):2876-2885(2009)Dong, K.B., et al. EMBO J. 27(20):2691-2701(2008)Villeneuve, L.M., et al. Proc. Natl. Acad. Sci. U.S.A. 105(26):9047-9052(2008)Brancorsini, S., et al. Cell Cycle 7(10):1415-1422(2008) |
Clonality |
Polyclonal |
Clone/Animal Names |
RB40179 |
Gene ID |
12419 |
Gene Name |
Cbx5 |
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
M |
Legend image 1 |
Mouse Cbx5 Antibody (C-term) (Cat. #AP19229b) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the Cbx5 antibody detected the Cbx5 protein (arrow). |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Other Accession |
P45973; NP_001070257.1 |
Predicted |
H |
Isotype |
Rabbit Ig |
Calculated MW |
22186 |
Antigen Region |
160-186 |
Antigen Source |
MOUSE |
Target/Specificity |
This Mouse Cbx5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-186 amino acids from the C-terminal region of mouse Cbx5. |
NCBI Accession |
NP_001070257.1; NP_001103686.1; NP_031652.1 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.