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DHH Antibody (Center)

DHH Antibody (Center)

Item no.	ABC-AP19172c-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Oncology Antibodies Blastoma Western Blot Primary Antibodies
Type	Antibody Polyclonal
Applications	Western Blot
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Desert hedgehog protein, DHH, HHG-3, Desert hedgehog protein N-product, Desert hedgehog protein C-product, DHH
Available
Primary Accession	O43323
Other Accession	Q61488; NP_066382.1
Antigen Type	Synthetic Peptide
Bio Background	This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development.
Bio References	Chinchilla, P., et al. Cell Cycle 9(3):570-579(2010) Bishop, B., et al. Nat. Struct. Mol. Biol. 16(7):698-703(2009) Hegde, G.V., et al. Mol. Cancer Res. 6(12):1928-1936(2008) Nakamura, M., et al. Fukuoka Igaku Zasshi 99(5):102-106(2008) Canto, P., et al. Mol. Hum. Reprod. 11(11):833-836(2005)
Gene ID	50846
Gene Name	DHH
Reactivity	H
Predicted	M
Calculated MW	43577
Antigen Region	195-223
Antigen Source	HUMAN
Target/Specificity	This DHH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-223 amino acids from the Central region of human DHH.
NCBI Accession	NP_066382.1

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Amount: 80 ul

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