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FZR1 Antibody (N-term)

FZR1 Antibody (N-term)

Item no.	ABC-AP19009a
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	CDH1, FZR1, FYR, FZR, KIAA1242, Fizzy-related protein homolog, CDC20-like protein 1, Cdh1/Hct1 homolog, Fzr, hCDH1
Available
Primary Accession	Q9UM11
Antigen Type	Synthetic Peptide
Application	WB
Bio Background	Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Bio References	Olson, J.E., et al. Breast Cancer Res. Treat. 125(1):221-228(2011) Colombo, S.L., et al. Proc. Natl. Acad. Sci. U.S.A. 107(44):18868-18873(2010) Naoe, H., et al. Mol. Cell. Biol. 30(16):3994-4005(2010) Sigl, R., et al. J. Cell. Sci. 122 (PT 22), 4208-4217 (2009) : Bassermann, F., et al. Cell 134(2):256-267(2008)
Clonality	Polyclonal
Clone/Animal Names	RB39496
Gene ID	51343
Gene Name	FZR1 (HGNC:24824)
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	FZR1 Antibody (N-term) (Cat. #AP19009a) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the FZR1 antibody detected the FZR1 protein (arrow).
Type image 1	WB
Dilution image 1	1:1000
Other Accession	Q9R1K5; NP_057347.2
Predicted	M
Isotype	Rabbit Ig
Calculated MW	55179
Antigen Region	53-81
Antigen Source	HUMAN
Target/Specificity	This FZR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-81 amino acids from the N-terminal region of human FZR1.
NCBI Accession	NP_001129669.1; NP_001129670.1; NP_057347.2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 9/6/2024

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