Item no. |
ABC-AP19009a-ev |
Manufacturer |
Abcepta
|
Amount |
80 ul |
Category |
|
Type |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applications |
WB |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
CDH1, FZR1, FYR, FZR, KIAA1242, Fizzy-related protein homolog, CDC20-like protein 1, Cdh1/Hct1 homolog, Fzr, hCDH1 |
Available |
|
Primary Accession |
Q9UM11 |
Antigen Type |
Synthetic Peptide |
Application |
WB |
Bio Background |
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. |
Bio References |
Olson, J.E., et al. Breast Cancer Res. Treat. 125(1):221-228(2011)Colombo, S.L., et al. Proc. Natl. Acad. Sci. U.S.A. 107(44):18868-18873(2010)Naoe, H., et al. Mol. Cell. Biol. 30(16):3994-4005(2010)Sigl, R., et al. J. Cell. Sci. 122 (PT 22), 4208-4217 (2009) :Bassermann, F., et al. Cell 134(2):256-267(2008) |
Clonality |
Polyclonal |
Clone/Animal Names |
RB39496 |
Gene ID |
51343 |
Gene Name |
|
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
FZR1 Antibody (N-term) (Cat. #AP19009a) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the FZR1 antibody detected the FZR1 protein (arrow). |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Other Accession |
Q9R1K5; NP_057347.2 |
Predicted |
M |
Isotype |
Rabbit Ig |
Calculated MW |
55179 |
Antigen Region |
53-81 |
Antigen Source |
HUMAN |
Target/Specificity |
This FZR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-81 amino acids from the N-terminal region of human FZR1. |
NCBI Accession |
NP_001129669.1; NP_001129670.1; NP_057347.2 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.