Item no. |
ABC-AP18848c |
Manufacturer |
Abcepta
|
Amount |
400 ul |
Category |
|
Type |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applications |
WB |
Specific against |
other |
Host |
Rabbit |
Isotype |
Ig |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
CDH20, PCDHGB4, FIB2, Protocadherin gamma-B4, Cadherin-20, Fibroblast cadherin-2, PCDH-gamma-B4 |
Available |
|
Primary Accession |
Q9UN71 |
Antigen Type |
Synthetic Peptide |
Application |
WB |
Bio Background |
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. This particular family member is expressed in fibroblasts and is thought to play a role in wound healing in response to injury. Alternative splicing has been described for the gamma cluster genes. |
Bio References |
Wu, Q., et al. Genome Res. 11(3):389-404(2001) Nollet, F., et al. J. Mol. Biol. 299(3):551-572(2000) Yagi, T., et al. Genes Dev. 14(10):1169-1180(2000) Wu, Q., et al. Proc. Natl. Acad. Sci. U.S.A. 97(7):3124-3129(2000) Wu, Q., et al. Cell 97(6):779-790(1999) |
Clonality |
Polyclonal |
Clone/Animal Names |
RB39608 |
Gene ID |
8641 |
Gene Name |
PCDHGB4 |
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
PCDHGB4 Antibody (Center)(Cat. #AP18848c) western blot analysis in Uterus tissue lysates (35ug/lane).This demonstrates the PCDHGB4 antibody detected the PCDHGB4 protein (arrow). |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Other Accession |
NP_003727.1 |
Isotype |
Rabbit Ig |
Calculated MW |
99927 |
Antigen Region |
353-379 |
Antigen Source |
HUMAN |
Target/Specificity |
This PCDHGB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 353-379 amino acids from the Central region of human PCDHGB4. |
NCBI Accession |
NP_003727.1; NP_115269.1 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.