Item no. |
ABC-AP18731B |
Manufacturer |
Abcepta
|
Amount |
400 ul |
Category |
|
Type |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applications |
WB, IF |
Specific against |
other |
Host |
Rabbit |
Isotype |
Ig |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
HOX4E, Homeobox protein Hox-4E, HOXD8, Homeobox protein Hox-D8, Homeobox protein Hox-54 |
Available |
|
Primary Accession |
P13378 |
Antigen Type |
Synthetic Peptide |
Application |
WB, IF |
Bio Background |
This gene belongs to the homeobox family of genes. Thehomeobox genes encode a highly conserved family of transcriptionfactors that play an important role in morphogenesis in allmulticellular organisms. Mammals possess four similar homeobox geneclusters, HOXA, HOXB, HOXC and HOXD, located on differentchromosomes, consisting of 9 to 11 genes arranged in tandem. Thisgene is one of several homeobox HOXD genes located in a cluster onchromosome 2. Deletions that remove the entire HOXD gene cluster orthe 5' end of this cluster have been associated with severe limband genital abnormalities. In addition to effects duringembryogenesis, this particular gene may also play a role in adulturogenital tract function. |
Bio References |
Ester, A.R., et al. Am. J. Med. Genet. A 149A (12), 2745-2752 (2009) :Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Harada, K., et al. J. Cell. Sci. 122 (PT 21), 3923-3930 (2009) :Goodman, F.R. Am. J. Med. Genet. 112(3):256-265(2002)Kosaki, K., et al. Teratology 65(2):50-62(2002) |
Clonality |
Polyclonal |
Clone/Animal Names |
RB37165 |
Gene ID |
3234 |
Gene Name |
HOXD8 |
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
Fluorescent image of HUVEC cell stained with HOXD8 Antibody (C-term)(Cat#AP18731b).HUVEC cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with HOXD8 primary antibody (1:25, 1 h at 37℃). For secondary antibody, Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37℃).Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37℃).HOXD8 immunoreactivity is localized to Nucleus significantly. |
Type image 1 |
IF |
Dilution image 1 |
1:10~50 |
Legend image 2 |
HOXD8 Antibody (C-term)(Cat. #AP18731b) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the HOXD8 antibody detected the HOXD8 protein (arrow). |
Type image 2 |
WB |
Dilution image 2 |
1:1000 |
Other Accession |
NP_062458.1 |
Isotype |
Rabbit Ig |
Calculated MW |
31911 |
Antigen Region |
243-270 |
Antigen Source |
HUMAN |
Target/Specificity |
This HOXD8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-270 amino acids from the C-terminal region of human HOXD8. |
NCBI Accession |
NP_001186675.1; NP_062458.1 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.