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OPTN Antibody (Center)

OPTN Antibody (Center)

Item no.	ABC-AP17993C-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Oncology Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Antibodies Carcinoma Western Blot Primary Antibodies
Type	Antibody Polyclonal
Applications	Western Blot
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Optineurin, E3-147K-interacting protein, FIP-2, Huntingtin yeast partner L, Huntingtin-interacting protein 7, HIP-7, Huntingtin-interacting protein L, NEMO-related protein, Optic neuropathy-inducing protein, Transcription factor IIIA-interacting protein,
Available
Primary Accession	Q96CV9
Other Accession	Q8R5M4; NP_068815.2
Antigen Type	Synthetic Peptide
Bio Background	This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
Bio References	McDonald, K.K., et al. J. Hum. Genet. 55(10):697-700(2010) Cheng, J.W., et al. Med. Sci. Monit. 16 (8), CR369-CR377 (2010) : Albagha, O.M., et al. Nat. Genet. 42(6):520-524(2010) Maruyama, H., et al. Nature 465(7295):223-226(2010) Park, B., et al. PLoS ONE 5 (7), E11547 (2010) :
Gene ID	10133
Gene Name	OPTN
Reactivity	H
Predicted	Rat
Calculated MW	65922
Antigen Region	71-96
Antigen Source	HUMAN
Target/Specificity	This OPTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-96 amino acids from the Central region of human OPTN.
NCBI Accession	NP_001008212.1; NP_001008213.1; NP_001008214.1; NP_068815.2

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Amount: 80 ul

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