HERPUD1 Antibody (N-term)

Synthetic Peptide

The accumulation of unfolded proteins in the endoplasmic
reticulum (ER) triggers the ER stress response. This response
includes the inhibition of translation to prevent further
accumulation of unfolded proteins, the increased expression of
proteins involved in polypeptide folding, known as the unfolded
protein response (UPR), and the destruction of misfolded proteins
by the ER-associated protein degradation (ERAD) system. This gene
may play a role in both UPR and ERAD. Its expression is induced by
UPR and it has an ER stress response element in its promoter region
while the encoded protein has an N-terminal ubiquitin-like domain
which may interact with the ERAD system. This protein has been
shown to interact with presenilin proteins and to increase the
level of amyloid-beta protein following its overexpression.
Alternative splicing of this gene produces multiple transcript
variants, some encoding different isoforms. The full-length nature
of all transcript variants has not been determined. [provided by
RefSeq].

Polyclonal

9709

Affinity Purified Rabbit Polyclonal Antibody (Pab)

HERPUD1 Antibody (N-term) (Cat. #AP17228a) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the HERPUD1 antibody detected the HERPUD1 protein (arrow).

1:1000

Rabbit Ig

55-83

This HERPUD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the N-terminal region of human HERPUD1.