Bio Background |
ADP-ribosylation factor 5 (ARF5) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2, and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. The ARF5 gene spans approximately 3.2kb of genomic DNA and contains six exons and five introns. [provided by RefSeq]. |
Bio References |
Shiba, T., et al. Proc. Natl. Acad. Sci. U.S.A. 103(42):15416-15421(2006) Austin, C., et al. Biochemistry 41(14):4669-4677(2002) Shin, O.H., et al. Biochemistry 40(36):10846-10852(2001) Nevrivy, D.J., et al. J. Biol. Chem. 275(22):16827-16836(2000) Kondo, A., et al. Mol. Biol. Cell 11(4):1315-1327(2000) |