Bio Background |
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family. |
Bio References |
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Lamesch, P., et al. Genomics 89(3):307-315(2007) Zhang, Z., et al. Genomics 81(5):468-480(2003) Kenmochi, N., et al. Genomics 77 (1-2), 65-70 (2001) : Suzuki, T., et al. J. Biol. Chem. 276(24):21724-21736(2001) |