Bio Background |
Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the retroposed gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in chromatin binding and gene suppression, and a catalytic domain believed to be involved in histone acetylation. Multiple proteins are encoded by transcript variants of this gene. |
Bio References |
Franz, H., et al. J. Biol. Chem. 284(50):35049-35059(2009) Landa, I., et al. PLoS Genet. 5 (9), E1000637 (2009) : Mulligan, P., et al. Mol. Cell 32(5):718-726(2008) Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006) Caron, C., et al. EMBO Rep. 4(9):877-882(2003) |