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KIDINS220 Antibody (C-term)

KIDINS220 Antibody (C-term)

Item no.	ABC-AP16256b-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Antibodies Western Blot Primary Antibodies
Type	Antibody Polyclonal
Applications	Western Blot
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Kinase D-interacting substrate of 220 kDa, Ankyrin repeat-rich membrane-spanning protein, KIDINS220, ARMS, KIAA1250
Available
Primary Accession	Q9ULH0
Other Accession	NP_065789.1
Antigen Type	Synthetic Peptide
Bio Background	KIDINS220 promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin-and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.
Bio References	Wu, Z., et al. J. Biol. Chem. 283(42):28198-28215(2008) Sniderhan, L.F., et al. Mol. Cell. Neurosci. 38(3):404-416(2008) Li, J., et al. J. Biol. Chem. 283(5):2614-2621(2008) Liao, Y.H., et al. Cancer Res. 67(24):11547-11556(2007) Bracale, A., et al. Mol. Biol. Cell 18(1):142-152(2007)
Gene ID	57498
Gene Name	KIDINS220
Reactivity	H
Calculated MW	196542
Antigen Region	1518-1547
Antigen Source	HUMAN
Target/Specificity	This KIDINS220 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1518-1547 amino acids from the C-terminal region of human KIDINS220.
NCBI Accession	NP_065789.1

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Amount: 80 ul

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