« Back
Home /
WHSC2 Antibody (Center)

WHSC2 Antibody (Center)

Item no.	ABC-AP14802c-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Antibodies Western Blot Primary Antibodies
Type	Antibody Polyclonal
Applications	Western Blot
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Negative elongation factor A, NELF-A, Wolf-Hirschhorn syndrome candidate 2 protein, NELFA, WHSC2
Available
Primary Accession	Q9H3P2
Other Accession	Q8BG30; NP_005654.3
Antigen Type	Synthetic Peptide
Bio Background	This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.
Bio References	Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Narita, T., et al. Mol. Cell 26(3):349-365(2007) Olsen, J.V., et al. Cell 127(3):635-648(2006) Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006) Ping, Y.H., et al. J. Biol. Chem. 276(16):12951-12958(2001)
Gene ID	7469
Gene Name	NELFA
Reactivity	H
Predicted	M
Calculated MW	57277
Antigen Region	251-279
Antigen Source	HUMAN
Target/Specificity	This WHSC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 251-279 amino acids from the Central region of human WHSC2.
NCBI Accession	NP_005654.3

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 80 ul

not available