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USP20 Antibody (Center)

USP20 Antibody (Center)

Item no.	ABC-AP14495C-ev
Manufacturer	Abcepta
Amount	80 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	USP20, KIAA1003, LSFR3A, VDU2, Ubiquitin carboxyl-terminal hydrolase 20, Deubiquitinating enzyme 20, Ubiquitin thioesterase 20, Ubiquitin-specific-processing protease 20, VHL-interacting deubiquitinating enzyme 2, hVDU2
Available
Primary Accession	Q9Y2K6
Antigen Type	Synthetic Peptide
Application	WB
Bio Background	Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'-and 'Lys-63'-linked polyubiquitin chains.
Bio References	Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010) Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010) Berthouze, M., et al. EMBO J. 28(12):1684-1696(2009) Olsen, J.V., et al. Cell 127(3):635-648(2006) Li, Z., et al. EMBO Rep. 6(4):373-378(2005)
Clonality	Polyclonal
Clone/Animal Names	RB34019
Gene ID	10868
Gene Name	USP20
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M
Legend image 1	USP20 Antibody (Center) (Cat. #AP14495c) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the USP20 antibody detected the USP20 protein (arrow).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	USP20 Antibody (Center) (Cat. #AP14495c) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the USP20 antibody detected the USP20 protein (arrow).
Type image 2	WB
Dilution image 2	1:1000
Other Accession	Q8C6M1; A7Z056; NP_006667.3; NP_001008563.2
Predicted	B
Isotype	Rabbit Ig
Calculated MW	102003
Antigen Region	310-339
Antigen Source	HUMAN
Target/Specificity	This USP20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 310-339 amino acids from the Central region of human USP20.
NCBI Accession	NP_001008563.2; NP_001103773.2; NP_006667.3

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 80 ul

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Delivery expected until 10/4/2024

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