Item no. |
ABC-AP14490b-ev |
Manufacturer |
Abcepta
|
Amount |
80 ul |
Category |
|
Type |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applications |
WB, IHC-P |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
COL1A1, Collagen alpha-1(I) chain, Alpha-1 type I collagen |
Available |
|
Primary Accession |
P02452 |
Antigen Type |
Synthetic Peptide |
Application |
WB, IHC-P |
Bio Background |
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish]. |
Bio References |
Blades, H.Z., et al. Bone 47(5):989-994(2010) Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) : Jin, H., et al. Osteoporos Int (2010) In press : Szczesny, G., et al. Arch Orthop Trauma Surg (2010) In press : Cheung, M.S., et al. J. Bone Miner. Res. (2010) In press : |
Clonality |
Polyclonal |
Clone/Animal Names |
RB33615 |
Gene ID |
1277 |
Gene Name |
COL1A1 |
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H, M |
Legend image 1 |
COL1A1 Antibody (C-term) (Cat. #AP14490b) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the COL1A1 antibody detected the COL1A1 protein (arrow). |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Legend image 2 |
COL1A1 Antibody (C-term) (Cat. #AP14490b)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of COL1A1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. |
Type image 2 |
IHC-P |
Dilution image 2 |
1:10~50 |
Other Accession |
P02454; P11087; P02457; P02453; NP_000079.2 |
Predicted |
B, C, Rat |
Isotype |
Rabbit Ig |
Calculated MW |
138941 |
Antigen Region |
1077-1106 |
Antigen Source |
HUMAN |
Target/Specificity |
This COL1A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1077-1106 amino acids from the C-terminal region of human COL1A1. |
NCBI Accession |
NP_000079.2 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.