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Mouse Pak4 Antibody (Center)

Mouse Pak4 Antibody (Center)

Item no.	ABC-AP14453C
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB, FC
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	Pak4, Kiaa1142, Serine/threonine-protein kinase PAK 4, p21-activated kinase 4, PAK-4
Available
Primary Accession	Q8BTW9
Antigen Type	Synthetic Peptide
Application	WB, FC
Bio Background	Pak4 activates the JNK pathway. Plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates ARHGEF2 (By similarity).
Bio References	Liu, Y., et al. Oncogene 29(44):5883-5894(2010) Tian, Y., et al. Mech. Dev. 126 (8-9), 710-720 (2009) : Ha, U.H., et al. J. Biol. Chem. 283(45):30624-30631(2008) Liu, Y., et al. Mol. Cancer Res. 6(7):1215-1224(2008) Danzer, K.M., et al. J. Neurochem. 103(6):2401-2407(2007)
Clonality	Polyclonal
Clone/Animal Names	RB34853
Gene ID	70584
Gene Name	Pak4
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M
Legend image 1	Mouse Pak4 Antibody (Center) (Cat. #AP14453c) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the Pak4 antibody detected the Pak4 protein (arrow).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Mouse Pak4 Antibody (Center) (Cat. #AP14453c) western blot analysis in Neuro-2a cell line lysates (35ug/lane).This demonstrates the Pak4 antibody detected the Pak4 protein (arrow).
Type image 2	WB
Dilution image 2	1:1000
Legend image 3	Mouse Pak4 Antibody (Center) (Cat. #AP14453c) flow cytometric analysis of Neuro-2a cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
Type image 3	FC
Dilution image 3	1:10~50
Other Accession	O96013; NP_081746.1
Isotype	Rabbit Ig
Calculated MW	64623
Antigen Region	187-216
Antigen Source	MOUSE
Target/Specificity	This Mouse Pak4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-216 amino acids from the Central region of mouse Pak4.
NCBI Accession	NP_081746.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 10/4/2024

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