Item no. |
ABC-AP14453C |
Manufacturer |
Abcepta
|
Amount |
400 ul |
Category |
|
Type |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applications |
WB, FC |
Specific against |
other |
Host |
Rabbit |
Isotype |
Ig |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
Pak4, Kiaa1142, Serine/threonine-protein kinase PAK 4, p21-activated kinase 4, PAK-4 |
Available |
|
Primary Accession |
Q8BTW9 |
Antigen Type |
Synthetic Peptide |
Application |
WB, FC |
Bio Background |
Pak4 activates the JNK pathway. Plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates ARHGEF2 (By similarity). |
Bio References |
Liu, Y., et al. Oncogene 29(44):5883-5894(2010)Tian, Y., et al. Mech. Dev. 126 (8-9), 710-720 (2009) :Ha, U.H., et al. J. Biol. Chem. 283(45):30624-30631(2008)Liu, Y., et al. Mol. Cancer Res. 6(7):1215-1224(2008)Danzer, K.M., et al. J. Neurochem. 103(6):2401-2407(2007) |
Clonality |
Polyclonal |
Clone/Animal Names |
RB34853 |
Gene ID |
70584 |
Gene Name |
Pak4 |
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H, M |
Legend image 1 |
Mouse Pak4 Antibody (Center) (Cat. #AP14453c) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the Pak4 antibody detected the Pak4 protein (arrow). |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Legend image 2 |
Mouse Pak4 Antibody (Center) (Cat. #AP14453c) western blot analysis in Neuro-2a cell line lysates (35ug/lane).This demonstrates the Pak4 antibody detected the Pak4 protein (arrow). |
Type image 2 |
WB |
Dilution image 2 |
1:1000 |
Legend image 3 |
Mouse Pak4 Antibody (Center) (Cat. #AP14453c) flow cytometric analysis of Neuro-2a cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis. |
Type image 3 |
FC |
Dilution image 3 |
1:10~50 |
Other Accession |
O96013; NP_081746.1 |
Isotype |
Rabbit Ig |
Calculated MW |
64623 |
Antigen Region |
187-216 |
Antigen Source |
MOUSE |
Target/Specificity |
This Mouse Pak4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-216 amino acids from the Central region of mouse Pak4. |
NCBI Accession |
NP_081746.1 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.