Item no. |
ABC-AP14374b-ev-80ul |
Manufacturer |
Abcepta
|
Amount |
80 ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
Western Blot |
Specific against |
other |
Host |
Rabbit |
Isotype |
Ig |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
GDNF family receptor alpha-2, GDNF receptor alpha-2, GDNFR-alpha-2, GFR-alpha-2, GDNF receptor beta, GDNFR-beta, Neurturin receptor alpha, NRTNR-alpha, NTNR-alpha, RET ligand 2, TGF-beta-related neurotrophic factor receptor 2, GFRA2, GDNFRB, RETL2, TRNR2 |
Available |
|
Primary Accession |
O00451 |
Other Accession |
O08842; NP_001486.4; NP_001158510.1; NP_001158511.1 |
Antigen Type |
Synthetic Peptide |
Bio Background |
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. |
Bio References |
Souza, R.P., et al. J Psychiatr Res 44(11):700-706(2010) Souza, R.P., et al. Psychopharmacology (Berl.) 210(3):347-354(2010) Buysschaert, I.D., et al. Allergy 65(5):616-622(2010) Lavedan, C., et al. Mol. Psychiatry 14(8):804-819(2009) Volpi, S., et al. J Clin Psychiatry 70(6):801-809(2009) |
Gene ID |
2675 |
Gene Name |
GFRA2 |
Reactivity |
H |
Predicted |
M |
Calculated MW |
51544 |
Antigen Region |
361-390 |
Antigen Source |
HUMAN |
Target/Specificity |
This GFRA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 361-390 amino acids from the C-terminal region of human GFRA2. |
NCBI Accession |
NP_001158510.1; NP_001158511.1; NP_001486.4 |
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