Item no. |
ABC-AP14212a-ev |
Manufacturer |
Abcepta
|
Amount |
80 ul |
Category |
|
Type |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applications |
WB |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
EVER1, TMC6, EVIN1, Transmembrane channel-like protein 6, Epidermodysplasia verruciformis protein 1, Protein LAK-4 |
Available |
|
Primary Accession |
Q7Z403 |
Antigen Type |
Synthetic Peptide |
Application |
WB |
Bio Background |
Epidermodysplasia verruciformis (EV) is an autosomalrecessive dermatosis characterized by abnormal susceptibility tohuman papillomaviruses (HPVs) and a high rate of progression tosquamous cell carcinoma on sun-exposed skin. EV is caused bymutations in either of two adjacent genes located on chromosome17q25.3. Both of these genes encode integral membrane proteins thatlocalize to the endoplasmic reticulum and are predicted to formtransmembrane channels. This gene encodes a transmembranechannel-like protein with 10 transmembrane domains and 2 leucinezipper motifs. |
Bio References |
McDermott, D.F., et al. Pediatr Dermatol 26(3):306-310(2009)Lazarczyk, M., et al. J. Exp. Med. 205(1):35-42(2008)Zuo, Y.G., et al. J. Dermatol. Sci. 44(3):153-159(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Donfack, J., et al. Int. J. Pediatr. Otorhinolaryngol. 70(7):1235-1240(2006) |
Clonality |
Polyclonal |
Clone/Animal Names |
RB34148 |
Gene ID |
11322 |
Gene Name |
TMC6 |
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
TMC6 Antibody (N-term) (Cat. #AP14212a) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the TMC6 antibody detected the TMC6 protein (arrow). |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Other Accession |
NP_009198.4; NP_001120670.1 |
Isotype |
Rabbit Ig |
Calculated MW |
90045 |
Antigen Region |
160-188 |
Antigen Source |
HUMAN |
Target/Specificity |
This TMC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-188 amino acids from the N-terminal region of human TMC6. |
NCBI Accession |
NP_001120670.1; NP_009198.4 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.