Alias |
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, PP2A B subunit isoform B'-gamma, PP2A B subunit isoform B56-gamma, PP2A B subunit isoform PR61-gamma, PP2A B subunit isoform R5-gamma, Renal carcinoma antigen NY-REN-29, PPP2 |
Bio Background |
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. |
Bio References |
Anney, R., et al. Hum. Mol. Genet. 19(20):4072-4082(2010) Lee, T.Y., et al. J. Biol. Chem. 285(28):21567-21580(2010) Shouse, G.P., et al. Oncogene 29(27):3933-3941(2010) Tung, H.Y., et al. FEBS Lett. 401 (2-3), 197-201 (1997) : McCright, B., et al. J. Biol. Chem. 271(36):22081-22089(1996) |