Item no. |
ABC-AP14012C |
Manufacturer |
Abcepta
|
Amount |
400 ul |
Category |
|
Type |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applications |
WB, IHC-P |
Specific against |
other |
Host |
Rabbit |
Isotype |
Ig |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
TLR8, Toll-like receptor 8, CD288 |
Available |
|
Primary Accession |
Q9NR97 |
Antigen Type |
Synthetic Peptide |
Application |
WB, IHC-P |
Bio Background |
The protein encoded by this gene is a member of theToll-like receptor (TLR) family which plays a fundamental role inpathogen recognition and activation of innate immunity. TLRs arehighly conserved from Drosophila to humans and share structural andfunctional similarities. They recognize pathogen-associatedmolecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for thedevelopment of effective immunity. The various TLRs exhibitdifferent patterns of expression. This gene is predominantlyexpressed in lung and peripheral blood leukocytes, and lies inclose proximity to another family member, TLR7, on chromosome X. |
Bio References |
Zannetti, C., et al. J. Biol. Chem. 285(45):34773-34780(2010)Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Cros, J., et al. Immunity 33(3):375-386(2010)Enevold, C., et al. Mult. Scler. 16(8):942-949(2010) |
Clonality |
Polyclonal |
Clone/Animal Names |
RB33953 |
Gene ID |
51311 |
Gene Name |
|
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
TLR8 Antibody (Center) (Cat. #AP14012c) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the TLR8 antibody detected the TLR8 protein (arrow). |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Legend image 2 |
TLR8 Antibody (Center) (AP14012c)immunohistochemistry analysis in formalin fixed and paraffin embedded human lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TLR8 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. |
Type image 2 |
IHC-P |
Dilution image 2 |
1:10~50 |
Other Accession |
NP_619542.1 |
Isotype |
Rabbit Ig |
Calculated MW |
119828 |
Antigen Region |
434-463 |
Antigen Source |
HUMAN |
Target/Specificity |
This TLR8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 434-463 amino acids from the Central region of human TLR8. |
NCBI Accession |
NP_619542.1 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.