Bio Background |
This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. |
Bio References |
Kim, B., et al. Psychiatry Res 179(2):121-125(2010) Caldinelli, L., et al. Protein Sci. 19(8):1500-1512(2010) Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010) Ohnuma, T., et al. Schizophr. Res. 118 (1-3), 300-302 (2010) : Mitchell, J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(16):7556-7561(2010) |