HTR2C Antibody (Center)

Synthetic Peptide

Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter,
elicits a wide array of physiological effects by binding to several
receptor subtypes, including the 5-HT2 family of
seven-transmembrane-spanning, G-protein-coupled receptors, which
activate phospholipase C and D signaling pathways. This gene
encodes the 2C subtype of serotonin receptor and its mRNA is
subject to multiple RNA editing events, where genomically encoded
adenosine residues are converted to inosines. RNA editing is
predicted to alter amino acids within the second intracellular loop
of the 5-HT2C receptor and generate receptor isoforms that differ
in their ability to interact with G proteins and the activation of
phospholipase C and D signaling cascades, thus modulating
serotonergic neurotransmission in the central nervous system.
Studies in humans have reported abnormalities in patterns of 5-HT2C
editing in depressed suicide victims.

Polyclonal

3358

Affinity Purified Rabbit Polyclonal Antibody (Pab)

HTR2C Antibody (Center) (Cat. #AP13896c) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the HTR2C antibody detected the HTR2C protein (arrow).

1:1000

Rabbit Ig

253-282

This HTR2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-282 amino acids from the Central region of human HTR2C.