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PYCARD Antibody (C-term)

PYCARD Antibody (C-term)

Item no.	ABC-AP13862b-ev
Manufacturer	Abcepta
Amount	80 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	ASC, TMS1, PYCARD, CARD5, Apoptosis-associated speck-like protein containing a CARD, Caspase recruitment domain-containing protein 5, PYD and CARD domain-containing protein, Target of methylation-induced silencing 1, hASC
Available
Primary Accession	Q9ULZ3
Antigen Type	Synthetic Peptide
Application	WB
Bio Background	This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.
Bio References	Grau, E., et al. J. Cancer Res. Clin. Oncol. 136(9):1415-1421(2010) Motani, K., et al. Cancer Sci. 101(8):1822-1827(2010) Mishra, B.B., et al. Cell. Microbiol. 12(8):1046-1063(2010) Cheng, J., et al. J. Cell. Physiol. 222(3):738-747(2010) McElvania Tekippe, E., et al. PLoS ONE 5 (8), E12320 (2010) :
Clonality	Polyclonal
Clone/Animal Names	RB33907
Gene ID	29108
Gene Name	PYCARD
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	PYCARD Antibody (C-term) (Cat. #AP13862b) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the PYCARD antibody detected the PYCARD protein (arrow).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Western blot analysis of lysate from THP-1 cell line, using PYCARD Antibody (C-term)(Cat. #AP13862b). AP13862b was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
Type image 2	WB
Dilution image 2	1:1000
Other Accession	NP_037390.2; NP_660183.1
Isotype	Rabbit Ig
Calculated MW	21627
Antigen Region	129-158
Antigen Source	HUMAN
Target/Specificity	This PYCARD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 129-158 amino acids from the C-terminal region of human PYCARD.
NCBI Accession	NP_037390.2; NP_660183.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 80 ul

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Delivery expected until 9/6/2024