MAVS Antibody (C-term)

NP_065797.2

Double-stranded RNA viruses are recognized in a cell
type-dependent manner by the transmembrane receptor TLR3 (MIM
603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and
RIGI (ROBO3; MIM 608630). These interactions initiate signaling
pathways that differ in their initial steps but converge in the
activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB
(IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1
(MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM
603734). Activated IRF3 and NFKB induce transcription of IFNB
(IFNB1; MIM 147640). For the TLR3 pathway, the intermediary
molecule before the pathways converge is the cytoplasmic protein
TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is
mitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed
16239922]).

57506

H

477-505

This MAVS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 477-505 amino acids from the C-terminal region of human MAVS.