Item no. |
ABC-AP12390c-ev |
Manufacturer |
Abcepta
|
Amount |
80 ul |
Category |
|
Type |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applications |
WB |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
MP1, mitochondrial, PITRM1, KIAA1104, Presequence protease, Pitrilysin metalloproteinase 1, hMP1, Metalloprotease 1, 3424-, hPreP |
Available |
|
Primary Accession |
Q5JRX3 |
Antigen Type |
Synthetic Peptide |
Application |
WB |
Bio Background |
ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. |
Bio References |
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Pinho, C.M., et al. Neurosci. Lett. 469(2):204-208(2010)Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)Yoshida, T., et al. Int. J. Mol. Med. 24(4):539-547(2009)Chow, K.M., et al. Biochemistry 48(13):2868-2877(2009) |
Clonality |
Polyclonal |
Clone/Animal Names |
RB31351 |
Gene ID |
10531 |
Gene Name |
|
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
PITRM1 Antibody (Center) (Cat. #AP12390c) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the PITRM1 antibody detected the PITRM1 protein (arrow). |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Other Accession |
NP_055704.2 |
Isotype |
Rabbit Ig |
Calculated MW |
117413 |
Antigen Region |
490-518 |
Antigen Source |
HUMAN |
Target/Specificity |
This PITRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 490-518 amino acids from the Central region of human PITRM1. |
NCBI Accession |
NP_001229236.1; NP_001229238.1; NP_055704.2 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.