ATF4 Antibody (Center)

NP_001666.2

This gene encodes a transcription factor that was
originally identified as a widely expressed mammalian DNA binding
protein that could bind a tax-responsive enhancer element in the
LTR of HTLV-1. The encoded protein was also isolated and
characterized as the cAMP-response element binding protein 2
(CREB-2). The protein encoded by this gene belongs to a family of
DNA-binding proteins that includes the AP-1 family of transcription
factors, cAMP-response element binding proteins (CREBs) and
CREB-like proteins. These transcription factors share a leucine
zipper region that is involved in protein-protein interactions,
located C-terminal to a stretch of basic amino acids that functions
as a DNA binding domain. Two alternative transcripts encoding the
same protein have been described. Two pseudogenes are located on
the X chromsome at q28 in a region containing a large inverted
duplication.

468

H

171-198

This ATF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-198 amino acids from the Central region of human ATF4.