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HIST3H3 Antibody (Center)

HIST3H3 Antibody (Center)

Manufacturer	Abcepta
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Specific against	other
Isotype	Ig
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB, FC
Amount	400 ul
Host	Rabbit
Item no.	ABC-AP12225c
eClass 6.1	32160702
eClass 9.0	32160702
Available
Primary Accession	Q16695
Antigen Type	Synthetic Peptide
Application	FC, WB
Bio Background	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq].
Bio References	Tachiwana, H., et al. Proc. Natl. Acad. Sci. U.S.A. 107(23):10454-10459(2010) Nair, S.S., et al. EMBO Rep. 11(6):438-444(2010) Rampakakis, E., et al. J. Cell. Biochem. 108(2):400-407(2009) Mochizuki, K., et al. Biochem. Biophys. Res. Commun. 371(2):324-327(2008) Meyer, K.D., et al. EMBO J. 27(10):1447-1457(2008)
Clonality	Polyclonal
Clone/Animal Names	RB31026
Gene ID	8290
Gene Name	H3-4 (HGNC:4778)
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	HIST3H3 Antibody (Center) (Cat. #AP12225c) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the HIST3H3 antibody detected the HIST3H3 protein (arrow).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	HIST3H3 Antibody (Center) (Cat. #AP12225c) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 2	FC
Dilution image 2	1:10~50
Other Accession	NP_003484.1
Isotype	Rabbit Ig
Calculated MW	15508
Antigen Region	50-78
Antigen Source	HUMAN
Target/Specificity	This HIST3H3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-78 amino acids from the Central region of human HIST3H3.
NCBI Accession	NP_003484.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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