Item no. |
ABC-AP11955B-ev-80ul |
Manufacturer |
Abcepta
|
Amount |
80 ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
Immunofluorescence, Western Blot, Flow cytometry |
Clone |
1773CT634.49.61 |
Specific against |
other |
Host |
Rabbit |
Isotype |
Ig |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
DNA damage-inducible transcript 3 protein, DDIT-3, C/EBP zeta, C/EBP-homologous protein, CHOP, C/EBP-homologous protein 10, CHOP-10, CCAAT/enhancer-binding protein homologous protein, Growth arrest and DNA damage-inducible protein GADD153, DDIT3, CHOP, CH |
Available |
|
Primary Accession |
P35638 |
Other Accession |
P35639; P14607; Q0IIB6; NP_004074 |
Antigen Type |
Synthetic Peptide |
Bio Background |
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. |
Bio References |
Park, S.H., et al. J. Immunol. 185(9):5522-5530(2010) Goodall, J.C., et al. Proc. Natl. Acad. Sci. U.S.A. 107(41):17698-17703(2010) Zhang, H.M., et al. J. Virol. 84(17):8446-8459(2010) Cazanave, S.C., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (1), G236-G243 (2010) : Wang, Y.L., et al. J. Exp. Clin. Cancer Res. 29, 54 (2010) : |
Gene ID |
1649 |
Gene Name |
DDIT3 |
Reactivity |
H, M |
Predicted |
B, Ha |
Calculated MW |
19175 |
Antigen Region |
120-149 |
Antigen Source |
HUMAN |
Target/Specificity |
This DDIT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-149 amino acids from the C-terminal region of human DDIT3. |
NCBI Accession |
NP_001181982.1; NP_001181983.1; NP_001181984.1; NP_001181986.1; NP_004074.2 |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.